DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SCF_FBW7_1

Location: 557:564

E3 ligase: FBXW7

DEGRON score: 0.9865

ASA_SCORE: 87.325

COIL: 0.9491

CONS_SCORE: 0.3385

DSS_SCORE: 0.433

HELIX: 0.0155

FCONS_SCORE: 1.0707

RIG_SCORE: 0.6725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G549V	TCGA-BQ-5880	KIRP	TCGA	LESTPVPS	DEG_SCF_FBW7_1	0.1111
p.G549V	DO20754	KIRP	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.1111
p.P563S	TCGA-DK-AA76	BLCA	TCGA	LESTPVPS	DEG_SCF_FBW7_1	0.5641
p.P563S	DO219013	BLCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.5641
p.M572T	TCGA-VQ-A91E	STAD	TCGA	LESTPVPS	DEG_SCF_FBW7_1	0.1111
p.M572T	DO51784	STAD	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.1111
p.P568A	DO48446	BLCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.2222
p.P574S	DO229010	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.P574S	DO229013	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.P574S	DO229016	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.P574S	DO229005	COCA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.P574S	DO228941	LICA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.P574S	DO229028	LICA	ICGC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.E558K	SIDM01119	Other Solid Cancers	GDSC	LESTPVPS	DEG_SCF_FBW7_1	0.591
p.E558K	ACH-000775	Lung Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	0.591
p.E558K	NCI-H727	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.591
p.V562M	SIDM00660	Colorectal Carcinoma	GDSC	LESTPVPS	DEG_SCF_FBW7_1	0.6097
p.V562M	ACH-000985	Colon/Colorectal Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	0.6097
p.V562M	LS-411N	large_intestine	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.6097
p.I570V	SIDM01134	Small Cell Lung Carcinoma	GDSC	LESTPVPS	DEG_SCF_FBW7_1	0.1667
p.I570V	ACH-000292	Lung Cancer	CCLE	LESTPVPS	DEG_SCF_FBW7_1	0.1667
p.I570V	NCI-H841	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.1667
p.S572G	CW-2	large_intestine	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.1111
p.Y574F	NCI-H650	lung	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.0556
p.V552I	Hs940-T	skin	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.1944
p.S561L	RCC-ER	kidney	COSMIC	LESTPVPS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SCF_FBW7_1	557:564	LESTPVPS	FBXW7	0.9865	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LESTPVPS

Degron related mutations and impact score

Drug responses associated with NUP214 mutations

All proteins holding degron of LESTPVPS