DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SPOP_SBC_1

Location: 1302:1306

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 81.18

COIL: 0.88

CONS_SCORE: 0.3061

DSS_SCORE: 0.6415

HELIX: 0.028

FCONS_SCORE: 1.0923

RIG_SCORE: 0.632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1307F	TCGA-C8-A1HL	BRCA	TCGA	ALSTT	DEG_SPOP_SBC_1	0.3056
p.S1307F	DO3952	BRCA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.S1307F	DO11854	GBM	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.L1310M	TCGA-VQ-A8P2	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2222
p.L1310M	DO51761	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2222
p.P1304L	DO227816	COCA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.7582
p.A1303T	DO228585	LICA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.7139
p.E1309K	DO37483	SKCM	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3611
p.S1307T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.S1307T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.A1302V	SIDM00217	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.5825
p.A1302V	ACH-000999	Colon/Colorectal Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.5825
p.A1302V	SNU-1040	large_intestine	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.5825
p.L1310F	NCI-H2170	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1302:1306	ALSTT	SPOP	0.9992	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7843:7847	ALSTT	SPOP	0.9031	More...
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_SPOP_SBC_1	391:395	ALSTT	SPOP	0.8379	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	541:545	ALSTT	SPOP	0.5091	More...
Q9NWS1	PCNA-interacting partner	DEG_SPOP_SBC_1	325:329	ALSTT	SPOP	0.8697	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	751:755	ALSTT	SPOP	0.6071	More...
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SPOP_SBC_1	604:608	ALSTT	SPOP	0.9866	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	68:72	ALSTT	SPOP	0.9981	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	574:578	ALSTT	SPOP	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons