FUNCTION: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-stran...
FUNCTION: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}.
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GO - Biological processes (BP):
DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]...
DNA repair [GO:0006281]; negative regulation of double-strand break repair via homologous recombination [GO:2000042]
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GO - Molecular function (MF):
DNA binding [GO:0003677]...
DNA binding [GO:0003677]
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GO - Cellular component (CC):
chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]...
chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]
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