DegronMD

Uniprot ID: Q9NWS1

Source protein: PCNA-interacting partner

Source gene: PARPBP

Class: DEG_SPOP_SBC_1

Location: 325:329

E3 ligase: SPOP

DEGRON score: 0.8697

ASA_SCORE: 61.76

COIL: 0.7016

CONS_SCORE: 0.3194

DSS_SCORE: 0.3997

HELIX: 0.2072

FCONS_SCORE: 0.7398

RIG_SCORE: 0.7734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T329P	TCGA-2W-A8YY	CESC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.7031
p.Q320E	TCGA-A2-A0EY	BRCA	TCGA	ALSTT	DEG_SPOP_SBC_1	0.1944
p.Q320E	DO3614	BRCA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.1944
p.N315H	TCGA-AZ-4315	COAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.0556
p.P333H	TCGA-BF-A1Q0	SKCM	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2222
p.A334G	TCGA-CG-5717	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.1944
p.A334G	DO38272	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	0.1944
p.I330L	DO233786	GACA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.V323F	DO229035	LICA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2778
p.R335Q	C3A	liver	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1302:1306	ALSTT	SPOP	0.9992	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7843:7847	ALSTT	SPOP	0.9031	More...
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_SPOP_SBC_1	391:395	ALSTT	SPOP	0.8379	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	541:545	ALSTT	SPOP	0.5091	More...
Q9NWS1	PCNA-interacting partner	DEG_SPOP_SBC_1	325:329	ALSTT	SPOP	0.8697	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	751:755	ALSTT	SPOP	0.6071	More...
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SPOP_SBC_1	604:608	ALSTT	SPOP	0.9866	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	68:72	ALSTT	SPOP	0.9981	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	574:578	ALSTT	SPOP	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons