DegronMD - Q9BSQ5(CCM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P37L	TCGA-17-Z061	LUAD	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.3056
p.D50E	TCGA-85-8048	LUSC	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2222
p.V41A	TCGA-A5-A0G2	UCEC	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.6936
p.R399H	TCGA-AJ-A3OJ	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.R399H	DO42753	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.S383N	TCGA-BR-7703	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1111
p.G394D	TCGA-BR-8078	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.7198
p.D52N	DO1285	BRCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.R46C	DO8514	COAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8301
p.R46C	DO41199	UCEC	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.8301
p.H46Y	DO222576	COCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7229
p.V47I	DO234204	ESAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.3056
p.E32D	DO223045	ESCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.1667
p.Q49H	DO11016	GBM	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.25
p.Q49H	DO37971	SKCM	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.25
p.V47F	DO228905	LICA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.3056
p.S56I	DO228971	LICA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0556
p.A386V	DO52686	MALY	ICGC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.D55N	DO38296	STAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.0833
p.S36L	SIDM02077	Colorectal Carcinoma	GDSC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2778
p.S405C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0556
p.S405C	NCI-H650	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0556
p.I401N	SIDM00213	Thyroid Gland Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.I401N	FTC-133	thyroid	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.E46K	SIDM00150	Colorectal Carcinoma	GDSC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7022
p.E46K	KM12	large intestine	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7022
p.I393T	SIDM01587	Bladder Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.7078
p.S48A	ACH-000786	Lymphoma	CCLE	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2778
p.S48A	Daudi	haematopoietic and lymphoid tissue	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation rewiring degron network	0.2778
p.S384C	ACH-000945	Lung Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation blocking phosphorylation signal	0.5833
p.S384C	NCI-H650	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation blocking phosphorylation signal	0.5833
p.G386S	ACH-000980	Lung Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.G386S	NCI-H1155	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1944
p.N401D	ACH-001060	Lymphoma	CCLE	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.1667
p.R404M	ACH-001517	Endometrial/Uterine Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.0833
p.T399A	ACH-002121	Skin Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.T399A	G-MEL	skin	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation rewiring degron network	0.2222
p.T393A	G-MEL	skin	COSMIC	ALSTT	DEG_SPOP_SBC_1	391:395	Mutation altering degron motif	0.7139
p.S42A	Daudi	haematopoietic and lymphoid tissue	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	38:46	Mutation altering degron motif	0.7588

Kaplan plot for CCM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCM2

UniProt ID: Q9BSQ5

Entrez ID: 83605

Protein name: Cerebral cavernous malformations 2 protein (Malcavernin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCM2 in