DegronMD

Uniprot ID: Q9BSQ5

Source protein: Cerebral cavernous malformations 2 protein

Source gene: CCM2

Class: DEG_APCC_DBOX_1

Location: 38:46

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9908

ASA_SCORE: 87.7889

COIL: 0.6662

CONS_SCORE: 0.6256

DSS_SCORE: 0.4077

HELIX: 0.1187

FCONS_SCORE: 1.2519

RIG_SCORE: 0.7705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P37L	TCGA-17-Z061	LUAD	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	0.3056
p.D50E	TCGA-85-8048	LUSC	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	0.2222
p.V41A	TCGA-A5-A0G2	UCEC	TCGA	ERRPLHTVV	DEG_APCC_DBOX_1	0.6936
p.D52N	DO1285	BRCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.1667
p.R46C	DO8514	COAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.8301
p.R46C	DO41199	UCEC	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.8301
p.H46Y	DO222576	COCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.7229
p.V47I	DO234204	ESAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.3056
p.E32D	DO223045	ESCA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.1667
p.Q49H	DO11016	GBM	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.25
p.Q49H	DO37971	SKCM	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.25
p.V47F	DO228905	LICA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.3056
p.S56I	DO228971	LICA	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.0556
p.D55N	DO38296	STAD	ICGC	ERRPLHTVV	DEG_APCC_DBOX_1	0.0833
p.S36L	SIDM02077	Colorectal Carcinoma	GDSC	ERRPLHTVV	DEG_APCC_DBOX_1	0.2778
p.E46K	SIDM00150	Colorectal Carcinoma	GDSC	ERRPLHTVV	DEG_APCC_DBOX_1	0.7022
p.E46K	KM12	large_intestine	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	0.7022
p.S48A	ACH-000786	Lymphoma	CCLE	ERRPLHTVV	DEG_APCC_DBOX_1	0.2778
p.S48A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	0.2778
p.S42A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ERRPLHTVV	DEG_APCC_DBOX_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_APCC_DBOX_1	38:46	ERRPLHTVV	APC,CDC20,FZR1	0.9908	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons