DegronMD

Uniprot ID: Q9BSQ5

Source protein: Cerebral cavernous malformations 2 protein

Source gene: CCM2

Class: DEG_SPOP_SBC_1

Location: 391:395

E3 ligase: SPOP

DEGRON score: 0.8379

ASA_SCORE: 78.4

COIL: 0.6718

CONS_SCORE: 0.4736

DSS_SCORE: 0.5876

HELIX: 0.0414

FCONS_SCORE: 0.9422

RIG_SCORE: 0.6717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R399H	TCGA-AJ-A3OJ	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2222
p.R399H	DO42753	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2222
p.S383N	TCGA-BR-7703	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.1111
p.G394D	TCGA-BR-8078	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.7198
p.A386V	DO52686	MALY	ICGC	ALSTT	DEG_SPOP_SBC_1	0.1944
p.S405C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.0556
p.S405C	NCI-H650	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.0556
p.I401N	SIDM00213	Thyroid Gland Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.1667
p.I401N	FTC-133	thyroid	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.1667
p.I393T	SIDM01587	Bladder Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.7078
p.S384C	ACH-000945	Lung Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.5833
p.S384C	NCI-H650	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.5833
p.G386S	ACH-000980	Lung Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.1944
p.G386S	NCI-H1155	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.1944
p.N401D	ACH-001060	Lymphoma	CCLE	ALSTT	DEG_SPOP_SBC_1	0.1667
p.R404M	ACH-001517	Endometrial/Uterine Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.0833
p.T399A	ACH-002121	Skin Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.2222
p.T399A	G-MEL	skin	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.2222
p.T393A	G-MEL	skin	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1302:1306	ALSTT	SPOP	0.9992	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7843:7847	ALSTT	SPOP	0.9031	More...
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_SPOP_SBC_1	391:395	ALSTT	SPOP	0.8379	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	541:545	ALSTT	SPOP	0.5091	More...
Q9NWS1	PCNA-interacting partner	DEG_SPOP_SBC_1	325:329	ALSTT	SPOP	0.8697	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	751:755	ALSTT	SPOP	0.6071	More...
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SPOP_SBC_1	604:608	ALSTT	SPOP	0.9866	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	68:72	ALSTT	SPOP	0.9981	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	574:578	ALSTT	SPOP	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons