DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
ALSTT
Uniprot ID:
Q9UKL3
Source protein:
CASP8-associated protein 2
Source gene:
CASP8AP2
Class:
DEG_SPOP_SBC_1
Location:
751:755
E3 ligase:
SPOP
DEGRON score:
0.6071
ASA_SCORE:
91.1
COIL:
0.846
CONS_SCORE:
0.2896
DSS_SCORE:
0.4526
HELIX:
0.086
FCONS_SCORE:
0.7785
RIG_SCORE:
0.7713
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CASP8AP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ALSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1302:1306
ALSTT
SPOP
0.9992
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7843:7847
ALSTT
SPOP
0.9031
More...
Q9BSQ5
Cerebral cavernous malformations 2 protein
DEG_SPOP_SBC_1
391:395
ALSTT
SPOP
0.8379
More...
Q9HCH0
Nck-associated protein 5-like
DEG_SPOP_SBC_1
541:545
ALSTT
SPOP
0.5091
More...
Q9NWS1
PCNA-interacting partner
DEG_SPOP_SBC_1
325:329
ALSTT
SPOP
0.8697
More...
Q9UKL3
CASP8-associated protein 2
DEG_SPOP_SBC_1
751:755
ALSTT
SPOP
0.6071
More...
Q9Y4R7
Tubulin monoglycylase TTLL3
DEG_SPOP_SBC_1
604:608
ALSTT
SPOP
0.9866
More...
O15480
Melanoma-associated antigen B3
DEG_SPOP_SBC_1
68:72
ALSTT
SPOP
0.9981
More...
Q8N1P7
Beta/gamma crystallin domain-containing protein 2
DEG_SPOP_SBC_1
574:578
ALSTT
SPOP
0.9809
More...