DegronMD

Uniprot ID: O15480

Source protein: Melanoma-associated antigen B3

Source gene: MAGEB3

Class: DEG_SPOP_SBC_1

Location: 68:72

E3 ligase: SPOP

DEGRON score: 0.9981

ASA_SCORE: 76.04

COIL: 0.8826

CONS_SCORE: 0.2558

DSS_SCORE: 0.4271

HELIX: 0.0434

FCONS_SCORE: 1.0908

RIG_SCORE: 0.6896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R59L	TCGA-33-AASL	LUSC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59L	DO219133	LUSC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.K80T	TCGA-AG-3892	READ	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2222
p.K80T	DO36394	READ	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2222
p.D76Y	TCGA-AP-A056	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2222
p.D76Y	DO43971	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2222
p.K63R	TCGA-BR-8485	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.3056
p.K63R	DO47823	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.Y79F	TCGA-CJ-5680	KIRC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.1389
p.Y79F	DO17607	KIRC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.1389
p.V75A	TCGA-CN-6021	HNSC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.25
p.V75A	TCGA-CR-7388	HNSC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.25
p.V75A	DO15847	HNSC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.25
p.V75A	DO14284	HNSC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.25
p.R59H	TCGA-D7-6522	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59H	DO222508	BTCA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59H	DO38384	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59H	SIDM01293	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.Q66H	TCGA-EO-A3AV	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.2778
p.Q66H	DO52412	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.2778
p.Q66H	SIDM00136	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.2778
p.Q66H	ACH-000552	Colon/Colorectal Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	0.2778
p.Q66H	HT-29	large_intestine	COSMIC	ALSTT	DEG_SPOP_SBC_1	0.2778
p.K63N	TCGA-EY-A1G8	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.3056
p.K63N	DO43578	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.3056
p.P65T	TCGA-NC-A5HM	LUSC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.25
p.P65T	DO219195	LUSC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.25
p.R59C	TCGA-Q1-A6DW	CESC	TCGA	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59C	DO44388	CESC	ICGC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.R59C	DO233844	GACA	ICGC	ALSTT	DEG_SPOP_SBC_1	0.0833
p.V75I	SIDM01664	Prostate Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1302:1306	ALSTT	SPOP	0.9992	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7843:7847	ALSTT	SPOP	0.9031	More...
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_SPOP_SBC_1	391:395	ALSTT	SPOP	0.8379	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	541:545	ALSTT	SPOP	0.5091	More...
Q9NWS1	PCNA-interacting partner	DEG_SPOP_SBC_1	325:329	ALSTT	SPOP	0.8697	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	751:755	ALSTT	SPOP	0.6071	More...
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SPOP_SBC_1	604:608	ALSTT	SPOP	0.9866	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	68:72	ALSTT	SPOP	0.9981	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	574:578	ALSTT	SPOP	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ALSTT

Degron related mutations and impact score

Drug responses associated with MAGEB3 mutations

All proteins holding degron of ALSTT