DegronMD - O15480(MAGEB3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R59L	TCGA-33-AASL	LUSC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59L	DO219133	LUSC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.K80T	TCGA-AG-3892	READ	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.2222
p.K80T	DO36394	READ	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.2222
p.A330D	TCGA-AP-A051	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	340:344	Mutation rewiring degron network	0.0556
p.A330D	DO42673	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	340:344	Mutation rewiring degron network	0.0556
p.D76Y	TCGA-AP-A056	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2222
p.D76Y	DO43971	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2222
p.K63R	TCGA-BR-8485	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.3056
p.K63R	DO47823	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.3056
p.Y79F	TCGA-CJ-5680	KIRC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.Y79F	DO17607	KIRC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1389
p.V75A	TCGA-CN-6021	HNSC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.V75A	TCGA-CR-7388	HNSC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.V75A	DO15847	HNSC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.V75A	DO14284	HNSC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.R59H	TCGA-D7-6522	STAD	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59H	DO222508	BTCA	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59H	DO38384	STAD	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59H	SIDM01293	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.S342N	TCGA-DU-6392	LGG	TCGA	ASSSS	DEG_SPOP_SBC_1	340:344	Mutation altering degron motif	0.818
p.S342N	DO22237	LGG	ICGC	ASSSS	DEG_SPOP_SBC_1	340:344	Mutation altering degron motif	0.818
p.Q66H	TCGA-EO-A3AV	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.Q66H	DO52412	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.Q66H	SIDM00136	Colorectal Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.Q66H	ACH-000552	Colon/Colorectal Cancer	CCLE	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.Q66H	HT-29	large intestine	COSMIC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.K63N	TCGA-EY-A1G8	UCEC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.3056
p.K63N	DO43578	UCEC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation substituting flanking lysine	0.3056
p.P65T	TCGA-NC-A5HM	LUSC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.P65T	DO219195	LUSC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.R59C	TCGA-Q1-A6DW	CESC	TCGA	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59C	DO44388	CESC	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R59C	DO233844	GACA	ICGC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.A338T	DO23511	LIRI	ICGC	ASSSS	DEG_SPOP_SBC_1	340:344	Mutation rewiring degron network	0.2778
p.V75I	SIDM01664	Prostate Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEB3

UniProt ID: O15480

Entrez ID: 4114

Protein name: Melanoma-associated antigen B3 (MAGE-B3 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGEB3 in