DegronMD

Uniprot ID: Q8N1P7

Source protein: Beta/gamma crystallin domain-containing protein 2

Source gene: CRYBG2

Class: DEG_SPOP_SBC_1

Location: 574:578

E3 ligase: SPOP

DEGRON score: 0.9809

ASA_SCORE: 80.82

COIL: 0.9064

CONS_SCORE: 0.7113

DSS_SCORE: 0.5692

HELIX: 0.0614

FCONS_SCORE: 0.929

RIG_SCORE: 0.6579

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R586K	SIDM00967	Ovarian Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.1111
p.R586K	SIDM00807	Bladder Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.1111
p.R586K	SIDM01133	Other Solid Cancers	GDSC	ALSTT	DEG_SPOP_SBC_1	0.1111
p.T581M	SIDM01002	Breast Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.25
p.G584R	SIDM01196	Hepatocellular Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	0.2778
p.S575C	SIDM01133	Other Solid Cancers	GDSC	ALSTT	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1302:1306	ALSTT	SPOP	0.9992	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	7843:7847	ALSTT	SPOP	0.9031	More...
Q9BSQ5	Cerebral cavernous malformations 2 protein	DEG_SPOP_SBC_1	391:395	ALSTT	SPOP	0.8379	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	541:545	ALSTT	SPOP	0.5091	More...
Q9NWS1	PCNA-interacting partner	DEG_SPOP_SBC_1	325:329	ALSTT	SPOP	0.8697	More...
Q9UKL3	CASP8-associated protein 2	DEG_SPOP_SBC_1	751:755	ALSTT	SPOP	0.6071	More...
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SPOP_SBC_1	604:608	ALSTT	SPOP	0.9866	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	68:72	ALSTT	SPOP	0.9981	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	574:578	ALSTT	SPOP	0.9809	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons