DegronMD - Q8N1P7(CRYBG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L332M	SIDM02050	Colorectal Carcinoma	GDSC	APSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.2778
p.P428L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.P428L	SIDM00087	Plasma Cell Myeloma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.P428L	SIDM00971	Breast Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.P428L	SIDM00847	Rhabdomyosarcoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.P428L	SIDM00793	Burkitt's Lymphoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.P428L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation substituting flanking lysine	0.3611
p.R586K	SIDM00967	Ovarian Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R586K	SIDM00807	Bladder Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.R586K	SIDM01133	Other Solid Cancers	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.1111
p.T581M	SIDM01002	Breast Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation rewiring degron network	0.25
p.G584R	SIDM01196	Hepatocellular Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation substituting flanking lysine	0.2778
p.E431K	SIDM00221	Melanoma	GDSC	APSTT	DEG_SPOP_SBC_1	421:425	Mutation rewiring degron network	0.1667
p.K717M	SIDM01133	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.K717M	NCI-H835	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.S575C	SIDM01133	Other Solid Cancers	GDSC	ALSTT	DEG_SPOP_SBC_1	574:578	Mutation altering degron motif	0.7541
p.D701G	BE2-M17	autonomic ganglia	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.D701G	H2731	pleura	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.D701G	BCPAP	thyroid	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.D701G	HPAC	pancreas	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.1667
p.R176C	CW-2	large intestine	COSMIC	VRTTT	DEG_SPOP_SBC_1	178:182	Mutation rewiring degron network	0.2778
p.V715L	LAN-6	autonomic ganglia	COSMIC	APSSS	DEG_SPOP_SBC_1	707:711	Mutation rewiring degron network	0.2222
p.P341S	MCC13	skin	COSMIC	APSST	DEG_SPOP_SBC_1	334:338	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRYBG2

UniProt ID: Q8N1P7

Entrez ID: 55057

Protein name: Beta/gamma crystallin domain-containing protein 2 (Absent in melanoma 1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRYBG2 in