DegronMD

Uniprot ID: Q8N1P7

Source protein: Beta/gamma crystallin domain-containing protein 2

Source gene: CRYBG2

Class: DEG_SPOP_SBC_1

Location: 178:182

E3 ligase: SPOP

DEGRON score: 0.7256

ASA_SCORE: 99.12

COIL: 0.7934

CONS_SCORE: 0.9835

DSS_SCORE: 0.4934

HELIX: 0.0174

FCONS_SCORE: 1.0568

RIG_SCORE: 0.812

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R176C	CW-2	large_intestine	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1491:1495	VRTTT	SPOP	0.9899	More...
Q96D05	Protein FAM241B	DEG_SPOP_SBC_1	18:22	VRTTT	SPOP	0.7851	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	329:333	VRTTT	SPOP	0.6499	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	178:182	VRTTT	SPOP	0.7256	More...
Q96KF7	Small integral membrane protein 8	DEG_SPOP_SBC_1	28:32	VRTTT	SPOP	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons