DegronMD - Q96KF7(SMIM8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R29H	TCGA-39-5037	LUSC	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	DO27429	LUSC	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	SIDM00654	Small Cell Lung Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	SIDM01608	Endometrial Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	ACH-000866	Lung Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R29H	NCI-H1048	lung	COSMIC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7133
p.R35H	TCGA-AP-A1DV	UCEC	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35H	DO43186	UCEC	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.L41P	TCGA-BP-5201	KIRC	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.L41P	DO17206	KIRC	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.R35C	TCGA-BR-8487	STAD	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	TCGA-EE-A2MJ	SKCM	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	TCGA-IB-7651	PAAD	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	DO46657	PAAD	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	DO38099	SKCM	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	DO47867	STAD	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	ACH-001333	Cervical Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.R35C	ACH-002273	Leukemia	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.25
p.E40D	TCGA-G6-A8L6	KIRC	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.E40D	DO50649	KIRC	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.Q21P	TCGA-HE-A5NH	KIRP	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.Q21P	DO44485	KIRP	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.G24V	TCGA-HU-8602	STAD	TCGA	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2222
p.G24V	DO47829	STAD	ICGC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2222
p.E19Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.E19Q	ACH-002176	Lung Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.E19Q	NCI-H748	lung	COSMIC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0833
p.V28M	SIDM01577	Plasma Cell Myeloma	GDSC	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7208
p.V28M	ACH-000889	Myeloma	CCLE	VRTTT	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7208

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMIM8

UniProt ID: Q96KF7

Entrez ID: 57150

Protein name: Small integral membrane protein 8

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMIM8 in