DegronMD

Uniprot ID: Q96KF7

Source protein: Small integral membrane protein 8

Source gene: SMIM8

Class: DEG_SPOP_SBC_1

Location: 28:32

E3 ligase: SPOP

DEGRON score: 0.6411

ASA_SCORE: 50.52

COIL: 0.5722

CONS_SCORE: 0.9332

DSS_SCORE: 0.3935

HELIX: 0.3326

FCONS_SCORE: 1.0318

RIG_SCORE: 0.8042

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R29H	TCGA-39-5037	LUSC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	DO27429	LUSC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	SIDM00654	Small Cell Lung Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	SIDM01608	Endometrial Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	ACH-000866	Lung Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	ACH-000990	Endometrial/Uterine Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R29H	NCI-H1048	lung	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.7133
p.R35H	TCGA-AP-A1DV	UCEC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35H	DO43186	UCEC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.25
p.L41P	TCGA-BP-5201	KIRC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.0833
p.L41P	DO17206	KIRC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.0833
p.R35C	TCGA-BR-8487	STAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	TCGA-EE-A2MJ	SKCM	TCGA	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	TCGA-IB-7651	PAAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	DO46657	PAAD	ICGC	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	DO38099	SKCM	ICGC	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	DO47867	STAD	ICGC	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	ACH-001333	Cervical Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	0.25
p.R35C	ACH-002273	Leukemia	CCLE	VRTTT	DEG_SPOP_SBC_1	0.25
p.E40D	TCGA-G6-A8L6	KIRC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1111
p.E40D	DO50649	KIRC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.1111
p.Q21P	TCGA-HE-A5NH	KIRP	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1389
p.Q21P	DO44485	KIRP	ICGC	VRTTT	DEG_SPOP_SBC_1	0.1389
p.G24V	TCGA-HU-8602	STAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.2222
p.G24V	DO47829	STAD	ICGC	VRTTT	DEG_SPOP_SBC_1	0.2222
p.E19Q	SIDM01117	Small Cell Lung Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.0833
p.E19Q	ACH-002176	Lung Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	0.0833
p.E19Q	NCI-H748	lung	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.0833
p.V28M	SIDM01577	Plasma Cell Myeloma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7208
p.V28M	ACH-000889	Myeloma	CCLE	VRTTT	DEG_SPOP_SBC_1	0.7208

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1491:1495	VRTTT	SPOP	0.9899	More...
Q96D05	Protein FAM241B	DEG_SPOP_SBC_1	18:22	VRTTT	SPOP	0.7851	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	329:333	VRTTT	SPOP	0.6499	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	178:182	VRTTT	SPOP	0.7256	More...
Q96KF7	Small integral membrane protein 8	DEG_SPOP_SBC_1	28:32	VRTTT	SPOP	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRTTT

Degron related mutations and impact score

Drug responses associated with SMIM8 mutations

All proteins holding degron of VRTTT