DegronMD

Uniprot ID: Q9NRF2

Source protein: SH2B adapter protein 1

Source gene: SH2B1

Class: DEG_SPOP_SBC_1

Location: 329:333

E3 ligase: SPOP

DEGRON score: 0.6499

ASA_SCORE: 64.8

COIL: 0.476

CONS_SCORE: 0.8105

DSS_SCORE: 0.4847

HELIX: 0.0136

FCONS_SCORE: 1.076

RIG_SCORE: 0.8058

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D328E	TCGA-17-Z036	LUAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.3056
p.A334D	TCGA-78-7150	LUAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.3056
p.A334D	DO24411	LUAD	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.A334D	SIDM00190	Melanoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.A334D	CP66-MEL	skin	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.R330W	TCGA-A8-A076	BRCA	TCGA	VRTTT	DEG_SPOP_SBC_1	0.7523
p.R330W	DO2617	BRCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.7523
p.R330W	DO222586	ESCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.7523
p.E341D	TCGA-AC-A23H	BRCA	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1111
p.E341D	TCGA-B0-5104	KIRC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1111
p.S324C	TCGA-EK-A3GK	CESC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1944
p.S324C	DO49964	CESC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.D339H	TCGA-G2-A2EJ	BLCA	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1667
p.D339H	DO554	BLCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.1667
p.R330G	TCGA-K4-A4AC	BLCA	TCGA	VRTTT	DEG_SPOP_SBC_1	0.6457
p.R330G	DO542	BLCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.6457
p.T331I	DO224744	COCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.7078
p.R320Q	ACH-000895	Colon/Colorectal Cancer	CCLE	VRTTT	DEG_SPOP_SBC_1	0.5278
p.R320Q	CL-34	large_intestine	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.5278
p.A326V	LCLC-97TM1	lung	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1491:1495	VRTTT	SPOP	0.9899	More...
Q96D05	Protein FAM241B	DEG_SPOP_SBC_1	18:22	VRTTT	SPOP	0.7851	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	329:333	VRTTT	SPOP	0.6499	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	178:182	VRTTT	SPOP	0.7256	More...
Q96KF7	Small integral membrane protein 8	DEG_SPOP_SBC_1	28:32	VRTTT	SPOP	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons