DegronMD

Uniprot ID: Q4ZHG4

Source protein: Fibronectin type III domain-containing protein 1

Source gene: FNDC1

Class: DEG_SPOP_SBC_1

Location: 1491:1495

E3 ligase: SPOP

DEGRON score: 0.9899

ASA_SCORE: 110.46

COIL: 0.9676

CONS_SCORE: 0.4307

DSS_SCORE: 0.8266

HELIX: 0.0176

FCONS_SCORE: 0.6129

RIG_SCORE: 0.7345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1492Q	TCGA-AA-A010	COAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.6218
p.R1481H	TCGA-AX-A3FT	UCEC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.0556
p.T1495M	TCGA-D1-A167	UCEC	TCGA	VRTTT	DEG_SPOP_SBC_1	0.7423
p.T1495M	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7423
p.T1495M	SIDM00100	Mesothelioma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7423
p.R1486H	TCGA-DM-A1HB	COAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486H	SIDM00683	Prostate Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1496W	TCGA-G4-6293	COAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.3056
p.R1496W	SIDM00613	Glioblastoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.R1486C	TCGA-NH-A50V	COAD	TCGA	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM01199	Hepatocellular Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM00607	Glioblastoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM01005	Acute Myeloid Leukemia	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM00358	Gastric Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM00252	Biliary Tract Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.R1486C	SIDM01782	Oral Cavity Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.1944
p.V1496D	DO227470	BRCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.E1493D	DO231196	LUSC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.6758
p.V1496I	DO227858	PBCA	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.V1496I	DO51761	STAD	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.V1496I	DO42113	UCEC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.V1496I	DO41199	UCEC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.3056
p.G1482D	DO41572	UCEC	ICGC	VRTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1491:1495	VRTTT	SPOP	0.9899	More...
Q96D05	Protein FAM241B	DEG_SPOP_SBC_1	18:22	VRTTT	SPOP	0.7851	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	329:333	VRTTT	SPOP	0.6499	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	178:182	VRTTT	SPOP	0.7256	More...
Q96KF7	Small integral membrane protein 8	DEG_SPOP_SBC_1	28:32	VRTTT	SPOP	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons