DegronMD

Uniprot ID: Q96D05

Source protein: Protein FAM241B

Source gene: FAM241B

Class: DEG_SPOP_SBC_1

Location: 18:22

E3 ligase: SPOP

DEGRON score: 0.7851

ASA_SCORE: 80.12

COIL: 0.7162

CONS_SCORE: 0.5792

DSS_SCORE: 0.7788

HELIX: 0.2396

FCONS_SCORE: 0.8011

RIG_SCORE: 0.715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T21A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7139
p.T21A	SIDM00667	Other Sarcomas	GDSC	VRTTT	DEG_SPOP_SBC_1	0.7139
p.D15N	SIDM00319	Melanoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.25
p.D15N	VMRC-MELG	skin	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.25
p.R31G	SIDM00481	Ovarian Carcinoma	GDSC	VRTTT	DEG_SPOP_SBC_1	0.0833
p.R31G	OAW-28	ovary	COSMIC	VRTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q4ZHG4	Fibronectin type III domain-containing protein 1	DEG_SPOP_SBC_1	1491:1495	VRTTT	SPOP	0.9899	More...
Q96D05	Protein FAM241B	DEG_SPOP_SBC_1	18:22	VRTTT	SPOP	0.7851	More...
Q9NRF2	SH2B adapter protein 1	DEG_SPOP_SBC_1	329:333	VRTTT	SPOP	0.6499	More...
Q8N1P7	Beta/gamma crystallin domain-containing protein 2	DEG_SPOP_SBC_1	178:182	VRTTT	SPOP	0.7256	More...
Q96KF7	Small integral membrane protein 8	DEG_SPOP_SBC_1	28:32	VRTTT	SPOP	0.6411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons