DegronMD - Q9Y4R7(TTLL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K753N	TCGA-AP-A0LM	UCEC	TCGA	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.0556
p.D772N	TCGA-D3-A3MR	SKCM	TCGA	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.25
p.R756M	TCGA-DU-6392	LGG	TCGA	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1389
p.F773V	TCGA-E6-A1LX	UCEC	TCGA	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.2222
p.F773V	DO41020	UCEC	ICGC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.2222
p.V601M	TCGA-HT-A4DS	LGG	TCGA	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.V601M	DO44554	LGG	ICGC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation rewiring degron network	0.25
p.A598T	DO224801	COCA	ICGC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation substituting flanking lysine	0.2778
p.A598T	DO233272	GACA	ICGC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation substituting flanking lysine	0.2778
p.L767F	SIDM00281	Other Solid Cancers	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.6981
p.L767F	DJM-1	skin	COSMIC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.6981
p.P777S	SIDM00193	Colorectal Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1111
p.P777S	SIDM00018	Acute Myeloid Leukemia	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1111
p.P777S	SIDM00158	Glioblastoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1111
p.P777S	SNU-81	large intestine	COSMIC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1111
p.H726R	SIDM00660	Colorectal Carcinoma	GDSC	VLDPTPNK	DEG_SCF_SKP2-CKS1_1	732:739	Mutation rewiring degron network	0.1667
p.H726R	LS-411N	large intestine	COSMIC	VLDPTPNK	DEG_SCF_SKP2-CKS1_1	732:739	Mutation rewiring degron network	0.1667
p.Q607K	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation altering degron motif	0.6944
p.Q607K	NCI-H2342	lung	COSMIC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation altering degron motif	0.6944
p.P769L	SIDM00302	Other Solid Cancers	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.7582
p.P769L	SIDM00161	Biliary Tract Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.7582
p.P769L	SIDM00163	Biliary Tract Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.7582
p.Q607H	SIDM01779	Gastric Carcinoma	GDSC	ALSTT	DEG_SPOP_SBC_1	604:608	Mutation altering degron motif	0.7582
p.P769S	SIDM01494	Glioblastoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.6752
p.P763L	ACH-000473	Bladder Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation altering degron motif	0.6471
p.R762K	ACH-002213	Head and Neck Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.3056
p.G755R	ACH-002397	Thyroid Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	763:769	Mutation rewiring degron network	0.1111

Kaplan plot for TTLL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTLL3

UniProt ID: Q9Y4R7

Entrez ID: 26140

Protein name: Tubulin monoglycylase TTLL3 (EC 6.3.2.-) (HOTTL) (Tubulin--tyrosine ligase-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTLL3 in