DegronMD

Uniprot ID: Q9Y4R7

Source protein: Tubulin monoglycylase TTLL3

Source gene: TTLL3

Class: DEG_SCF_FBW7_1

Location: 763:769

E3 ligase: FBXW7

DEGRON score: 0.9276

ASA_SCORE: 68.7

COIL: 0.8893

CONS_SCORE: 0.1639

DSS_SCORE: 0.7267

HELIX: 0.0393

FCONS_SCORE: 1.0116

RIG_SCORE: 0.6719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K753N	TCGA-AP-A0LM	UCEC	TCGA	PCTPGST	DEG_SCF_FBW7_1	0.0556
p.D772N	TCGA-D3-A3MR	SKCM	TCGA	PCTPGST	DEG_SCF_FBW7_1	0.25
p.R756M	TCGA-DU-6392	LGG	TCGA	PCTPGST	DEG_SCF_FBW7_1	0.1389
p.F773V	TCGA-E6-A1LX	UCEC	TCGA	PCTPGST	DEG_SCF_FBW7_1	0.2222
p.F773V	DO41020	UCEC	ICGC	PCTPGST	DEG_SCF_FBW7_1	0.2222
p.L767F	SIDM00281	Other Solid Cancers	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.6981
p.L767F	DJM-1	skin	COSMIC	PCTPGST	DEG_SCF_FBW7_1	0.6981
p.P777S	SIDM00193	Colorectal Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.1111
p.P777S	SIDM00018	Acute Myeloid Leukemia	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.1111
p.P777S	SIDM00158	Glioblastoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.1111
p.P777S	SNU-81	large_intestine	COSMIC	PCTPGST	DEG_SCF_FBW7_1	0.1111
p.P769L	SIDM00302	Other Solid Cancers	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.7582
p.P769L	SIDM00161	Biliary Tract Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.7582
p.P769L	SIDM00163	Biliary Tract Carcinoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.7582
p.P769S	SIDM01494	Glioblastoma	GDSC	PCTPGST	DEG_SCF_FBW7_1	0.6752
p.P763L	ACH-000473	Bladder Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	0.6471
p.R762K	ACH-002213	Head and Neck Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	0.3056
p.G755R	ACH-002397	Thyroid Cancer	CCLE	PCTPGST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4R7	Tubulin monoglycylase TTLL3	DEG_SCF_FBW7_1	763:769	PCTPGST	FBXW7	0.9276	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons