DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VLDPTPNK
Uniprot ID:
Q9Y4R7
Source protein:
Tubulin monoglycylase TTLL3
Source gene:
TTLL3
Class:
DEG_SCF_SKP2-CKS1_1
Location:
732:739
E3 ligase:
SKP2,CSK1
DEGRON score:
0.8855
ASA_SCORE:
70.625
COIL:
0.6895
CONS_SCORE:
0.2445
DSS_SCORE:
0.341
HELIX:
0.2416
FCONS_SCORE:
1.0698
RIG_SCORE:
0.7811
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.H726R
SIDM00660
Colorectal Carcinoma
GDSC
VLDPTPNK
DEG_SCF_SKP2-CKS1_1
0.1667
p.H726R
LS-411N
large_intestine
COSMIC
VLDPTPNK
DEG_SCF_SKP2-CKS1_1
0.1667
Drug responses associated with TTLL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLDPTPNK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y4R7
Tubulin monoglycylase TTLL3
DEG_SCF_SKP2-CKS1_1
732:739
VLDPTPNK
SKP2,CSK1
0.8855
More...