DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ALSTT
Uniprot ID:
Q9HCH0
Source protein:
Nck-associated protein 5-like
Source gene:
NCKAP5L
Class:
DEG_SPOP_SBC_1
Location:
541:545
E3 ligase:
SPOP
DEGRON score:
0.5091
ASA_SCORE:
88.44
COIL:
0.9088
CONS_SCORE:
0.6612
DSS_SCORE:
0.5999
HELIX:
0.0518
FCONS_SCORE:
0.8987
RIG_SCORE:
0.6633
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q534H
TCGA-22-1000
LUSC
TCGA
ALSTT
DEG_SPOP_SBC_1
0.1389
p.Q534H
DO27060
LUSC
ICGC
ALSTT
DEG_SPOP_SBC_1
0.1389
p.G549C
TCGA-91-A4BC
LUAD
TCGA
ALSTT
DEG_SPOP_SBC_1
0.2222
p.G549C
DO45422
LUAD
ICGC
ALSTT
DEG_SPOP_SBC_1
0.2222
p.L535P
TCGA-UY-A8OB
BLCA
TCGA
ALSTT
DEG_SPOP_SBC_1
0.1667
p.L535P
DO219037
BLCA
ICGC
ALSTT
DEG_SPOP_SBC_1
0.1667
p.R536K
SIDM01206
Neuroblastoma
GDSC
ALSTT
DEG_SPOP_SBC_1
0.1944
p.R536K
ACH-002248
Neuroblastoma
CCLE
ALSTT
DEG_SPOP_SBC_1
0.1944
p.R536K
IMR-5
autonomic_ganglia
COSMIC
ALSTT
DEG_SPOP_SBC_1
0.1944
p.P538L
SIDM01480
Ovarian Carcinoma
GDSC
ALSTT
DEG_SPOP_SBC_1
0.25
p.P538L
ACH-000256
Ovarian Cancer
CCLE
ALSTT
DEG_SPOP_SBC_1
0.25
p.T544S
ACH-001523
Skin Cancer
CCLE
ALSTT
DEG_SPOP_SBC_1
0.6005
Drug responses associated with NCKAP5L mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ALSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P35658
Nuclear pore complex protein Nup214
DEG_SPOP_SBC_1
1302:1306
ALSTT
SPOP
0.9992
More...
Q7Z5P9
Mucin-19
DEG_SPOP_SBC_1
7843:7847
ALSTT
SPOP
0.9031
More...
Q9BSQ5
Cerebral cavernous malformations 2 protein
DEG_SPOP_SBC_1
391:395
ALSTT
SPOP
0.8379
More...
Q9HCH0
Nck-associated protein 5-like
DEG_SPOP_SBC_1
541:545
ALSTT
SPOP
0.5091
More...
Q9NWS1
PCNA-interacting partner
DEG_SPOP_SBC_1
325:329
ALSTT
SPOP
0.8697
More...
Q9UKL3
CASP8-associated protein 2
DEG_SPOP_SBC_1
751:755
ALSTT
SPOP
0.6071
More...
Q9Y4R7
Tubulin monoglycylase TTLL3
DEG_SPOP_SBC_1
604:608
ALSTT
SPOP
0.9866
More...
O15480
Melanoma-associated antigen B3
DEG_SPOP_SBC_1
68:72
ALSTT
SPOP
0.9981
More...
Q8N1P7
Beta/gamma crystallin domain-containing protein 2
DEG_SPOP_SBC_1
574:578
ALSTT
SPOP
0.9809
More...