DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_COP1_1

Location: 1568:1577

E3 ligase: COP1

DEGRON score: 0.9934

ASA_SCORE: 78.54

COIL: 0.9349

CONS_SCORE: 0.2888

DSS_SCORE: 0.5409

HELIX: 0.0351

FCONS_SCORE: 0.8786

RIG_SCORE: 0.6911

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1578M	TCGA-AX-A064	UCEC	TCGA	TPATTGVPDA	DEG_COP1_1	0.3056
p.L1560I	TCGA-CR-7388	HNSC	TCGA	TPATTGVPDA	DEG_COP1_1	0.1111
p.R1579M	DO43073	UCEC	ICGC	TPATTGVPDA	DEG_COP1_1	0.2778
p.S1579F	DO43971	UCEC	ICGC	TPATTGVPDA	DEG_COP1_1	0.2778
p.P1581S	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	TPATTGVPDA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_COP1_1	1568:1577	TPATTGVPDA	COP1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons