DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SCF_FBW7_1

Location: 1227:1233

E3 ligase: FBXW7

DEGRON score: 0.9759

ASA_SCORE: 82.5286

COIL: 0.9136

CONS_SCORE: 0.3056

DSS_SCORE: 0.4995

HELIX: 0.0151

FCONS_SCORE: 1.0243

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1227L	TCGA-55-6543	LUAD	TCGA	IITPTPS	DEG_SCF_FBW7_1	0.6063
p.P1232L	TCGA-AX-A1CE	UCEC	TCGA	IITPTPS	DEG_SCF_FBW7_1	0.6471
p.G1241W	TCGA-GN-A26D	SKCM	TCGA	IITPTPS	DEG_SCF_FBW7_1	0.1111
p.S1219L	TCGA-XF-AAN3	BLCA	TCGA	IITPTPS	DEG_SCF_FBW7_1	0.1111
p.T1236A	DO229344	BTCA	ICGC	IITPTPS	DEG_SCF_FBW7_1	0.25
p.G1231V	DO23330	LINC	ICGC	IITPTPS	DEG_SCF_FBW7_1	0.7532
p.I1217L	DO24208	LUAD	ICGC	IITPTPS	DEG_SCF_FBW7_1	0.0556
p.G1231W	DO37480	SKCM	ICGC	IITPTPS	DEG_SCF_FBW7_1	0.7825
p.D1243N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IITPTPS	DEG_SCF_FBW7_1	0.0556
p.G1236R	GI-1	central_nervous_system	COSMIC	IITPTPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SCF_FBW7_1	1227:1233	IITPTPS	FBXW7	0.9759	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons