DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SCF_FBW7_1

Location: 1200:1207

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 75.65

COIL: 0.9029

CONS_SCORE: 0.2903

DSS_SCORE: 0.4874

HELIX: 0.0349

FCONS_SCORE: 0.9992

RIG_SCORE: 0.6862

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1195N	TCGA-C5-A8XK	CESC	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	0.3056
p.A1190T	TCGA-CK-4948	COAD	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	0.0556
p.S1215L	TCGA-EE-A2MJ	SKCM	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	0.1111
p.S1207Y	TCGA-EO-A22U	UCEC	TCGA	VTSTPSAS	DEG_SCF_FBW7_1	0.712
p.S1209L	DO219053	BLCA	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	0.2778
p.K1202N	DO229036	LICA	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	0.6918
p.I1217L	DO24208	LUAD	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	0.0556
p.S1216L	DO38099	SKCM	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	0.0833
p.S1197Y	DO43755	UCEC	ICGC	VTSTPSAS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SCF_FBW7_1	1200:1207	VTSTPSAS	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons