DegronMD

Uniprot ID: P35658

Source protein: Nuclear pore complex protein Nup214

Source gene: NUP214

Class: DEG_SCF_FBW7_1

Location: 530:537

E3 ligase: FBXW7

DEGRON score: 0.9981

ASA_SCORE: 77.3375

COIL: 0.9384

CONS_SCORE: 0.2923

DSS_SCORE: 0.428

HELIX: 0.0216

FCONS_SCORE: 0.977

RIG_SCORE: 0.6376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S526F	TCGA-56-8625	LUSC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.2222
p.S526F	DO45515	LUSC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.2222
p.L530V	TCGA-86-8674	LUAD	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.5654
p.L530V	DO25535	LUAD	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.5654
p.S521Y	TCGA-CA-6718	COAD	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.0833
p.S521Y	DO7801	COAD	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.0833
p.F522V	TCGA-EO-A22R	UCEC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.1111
p.F522V	DO42713	UCEC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.1111
p.F520L	TCGA-QK-AA3K	HNSC	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.0556
p.F520L	DO48446	BLCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.0556
p.F520L	DO52102	HNSC	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.0556
p.S529F	TCGA-W3-AA1R	SKCM	TCGA	LAPTPAAS	DEG_SCF_FBW7_1	0.3056
p.S529F	DO51275	SKCM	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.3056
p.S545L	DO48446	BLCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.1111
p.S545L	SIDM00401	Melanoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	0.1111
p.P532L	DO229003	COCA	ICGC	LAPTPAAS	DEG_SCF_FBW7_1	0.6471
p.P532L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	0.6471
p.P532L	SIDM00581	Glioblastoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	0.6471
p.A535V	SIDM01451	Pancreatic Carcinoma	GDSC	LAPTPAAS	DEG_SCF_FBW7_1	0.5825
p.A535V	ACH-000933	Pancreatic Cancer	CCLE	LAPTPAAS	DEG_SCF_FBW7_1	0.5825
p.P525S	ACH-001515	Cervical Cancer	CCLE	LAPTPAAS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SCF_FBW7_1	530:537	LAPTPAAS	FBXW7	0.9981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons