DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10943:10947

E3 ligase: SPOP

DEGRON score: 0.7326

ASA_SCORE: 85.46

COIL: 0.8474

CONS_SCORE: 0

DSS_SCORE: 0.2858

HELIX: 0.0154

FCONS_SCORE: 0

RIG_SCORE: 0.7909

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G10957C	TCGA-09-2044	OV	TCGA	AVTST	DEG_SPOP_SBC_1	0.0556
p.G10957C	DO28923	OV	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.S10941Y	TCGA-19-5956	GBM	TCGA	AVTST	DEG_SPOP_SBC_1	0.2778
p.S10941Y	DO13863	GBM	ICGC	AVTST	DEG_SPOP_SBC_1	0.2778
p.A10943S	TCGA-44-5643	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	0.7588
p.A10943S	DO25508	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.7588
p.L10937V	TCGA-4Z-AA80	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1667
p.L10937V	TCGA-66-2785	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1667
p.L10937V	TCGA-E7-A6MD	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1667
p.L10937V	DO218986	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.L10937V	DO219015	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.L10937V	DO26520	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.T10953I	TCGA-B5-A3FA	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	0.1667
p.T10953I	DO52402	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1667
p.S10955Y	TCGA-DK-A6AW	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	0.1111
p.S10955Y	DO48566	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1111
p.F10954L	DO227451	EOPC	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.F10954L	DO228579	GACA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.F10954L	DO233286	GACA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.F10954L	DO228921	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.F10954L	DO228899	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.1389
p.L10956P	DO227451	EOPC	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.L10956P	DO234333	ESAD	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.L10956P	DO228921	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.L10956P	DO228899	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.0833
p.T10948N	DO229025	LICA	ICGC	AVTST	DEG_SPOP_SBC_1	0.3056
p.V10933G	DO220855	MELA	ICGC	AVTST	DEG_SPOP_SBC_1	0.0556
p.S10946R	DO51493	PACA	ICGC	AVTST	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1199:1203	AVTST	SPOP	0.9994	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	252:256	AVTST	SPOP	0.7838	More...
Q15154	Pericentriolar material 1 protein	DEG_SPOP_SBC_1	791:795	AVTST	SPOP	0.996	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1539:1543	AVTST	SPOP	0.9633	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1892:1896	AVTST	SPOP	0.8213	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1790:1794	AVTST	SPOP	0.9943	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	852:856	AVTST	SPOP	0.9732	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1280:1284	AVTST	SPOP	0.9995	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10943:10947	AVTST	SPOP	0.7326	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10997:11001	AVTST	SPOP	0.6888	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11107:11111	AVTST	SPOP	0.8831	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11161:11165	AVTST	SPOP	0.9464	More...
Q9ULR3	Protein phosphatase 1H	DEG_SPOP_SBC_1	109:113	AVTST	SPOP	0.9954	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	353:357	AVTST	SPOP	0.6075	More...
Q9H195	Mucin-3B	DEG_SPOP_SBC_1	253:257	AVTST	SPOP	0.7286	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AVTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of AVTST