DegronMD

Uniprot ID: Q15154

Source protein: Pericentriolar material 1 protein

Source gene: PCM1

Class: DEG_SCF_FBW7_1

Location: 875:881

E3 ligase: FBXW7

DEGRON score: 0.9595

ASA_SCORE: 83.3286

COIL: 0.7867

CONS_SCORE: 0.3943

DSS_SCORE: 0.5788

HELIX: 0.1579

FCONS_SCORE: 0.7249

RIG_SCORE: 0.704

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T886M	TCGA-DU-6392	LGG	TCGA	LCTPQQS	DEG_SCF_FBW7_1	0.1944
p.T886M	DO22237	LGG	ICGC	LCTPQQS	DEG_SCF_FBW7_1	0.1944
p.K885E	TCGA-E6-A1LX	UCEC	TCGA	LCTPQQS	DEG_SCF_FBW7_1	0.3333
p.K885E	DO41020	UCEC	ICGC	LCTPQQS	DEG_SCF_FBW7_1	0.3333
p.S866T	DO232832	NACA	ICGC	LCTPQQS	DEG_SCF_FBW7_1	0.5278
p.D870G	DO229259	THCA	ICGC	LCTPQQS	DEG_SCF_FBW7_1	0.1944
p.G871V	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01265	Plasma Cell Myeloma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00773	Non-Cancerous	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00454	Rhabdomyosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00393	Gastric Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01126	Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00087	Plasma Cell Myeloma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00846	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00654	Small Cell Lung Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00690	Head and Neck Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00210	Ovarian Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01112	Osteosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00878	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00309	Mesothelioma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01147	Gastric Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00793	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00954	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00863	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00774	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00720	Mesothelioma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00808	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01173	Rhabdomyosarcoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00785	Acute Myeloid Leukemia	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM00628	Breast Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01318	Hepatocellular Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01664	Prostate Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.G871V	SIDM01254	Burkitt's Lymphoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.2222
p.P878L	SIDM00889	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.7582
p.P878L	ACH-001333	Cervical Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	0.7582
p.P878L	C-33-A	cervix	COSMIC	LCTPQQS	DEG_SCF_FBW7_1	0.7582
p.R882G	SIDM00381	Cervical Carcinoma	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.R882G	SIDM01470	Acute Myeloid Leukemia	GDSC	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.R882G	ACH-000387	Leukemia	CCLE	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.R882G	ACH-001518	Endometrial/Uterine Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.R882G	ACH-002020	Cervical Cancer	CCLE	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.N874T	ACH-001991	Primary	CCLE	LCTPQQS	DEG_SCF_FBW7_1	0.3056
p.P879L	C-33-A	cervix	COSMIC	LCTPQQS	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LCTPQQS

Degron related mutations and impact score

Drug responses associated with PCM1 mutations

All proteins holding degron of LCTPQQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15154	Pericentriolar material 1 protein	DEG_SCF_FBW7_1	875:881	LCTPQQS	FBXW7	0.9595	More...