DegronMD

Uniprot ID: Q15154

Source protein: Pericentriolar material 1 protein

Source gene: PCM1

Class: DEG_APCC_DBOX_1

Location: 496:504

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6836

ASA_SCORE: 110.3222

COIL: 0.0606

CONS_SCORE: 0.7608

DSS_SCORE: 0.3775

HELIX: 0.9421

FCONS_SCORE: 1.2213

RIG_SCORE: 0.7835

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R497Q	TCGA-BK-A6W3	UCEC	TCGA	VRKRLNELR	DEG_APCC_DBOX_1	0.7329
p.R497Q	DO229058	LICA	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	0.7329
p.R497Q	DO50076	UCEC	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	0.7329
p.N494S	DO229211	THCA	ICGC	VRKRLNELR	DEG_APCC_DBOX_1	0.2778
p.E502D	SIDM02035	Colorectal Carcinoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	0.5647
p.K489R	SIDM00537	Colorectal Carcinoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	0.5833
p.K489R	ACH-001345	Colon/Colorectal Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	0.5833
p.K489R	GP5d	large_intestine	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	0.5833
p.R504S	SIDM00201	Ewing's Sarcoma	GDSC	VRKRLNELR	DEG_APCC_DBOX_1	0.6316
p.R504S	ACH-002119	Bone Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	0.6316
p.R504S	EW-7	bone	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	0.6316
p.T513A	ACH-000982	Colon/Colorectal Cancer	CCLE	VRKRLNELR	DEG_APCC_DBOX_1	0.0833
p.S502L	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VRKRLNELR	DEG_APCC_DBOX_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15154	Pericentriolar material 1 protein	DEG_APCC_DBOX_1	496:504	VRKRLNELR	APC,CDC20,FZR1	0.6836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons