DegronMD

Uniprot ID: Q9H1U4

Source protein: Multiple epidermal growth factor-like domains protein 9

Source gene: MEGF9

Class: DEG_SCF_FBW7_1

Location: 156:162

E3 ligase: FBXW7

DEGRON score: 0.622

ASA_SCORE: 84.9286

COIL: 0.9177

CONS_SCORE: 0.6117

DSS_SCORE: 0.7331

HELIX: 0.0283

FCONS_SCORE: 0.9531

RIG_SCORE: 0.651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P154Q	TCGA-CV-6959	HNSC	TCGA	PTTPVAT	DEG_SCF_FBW7_1	0.2778
p.P154Q	TCGA-D3-A2J6	SKCM	TCGA	PTTPVAT	DEG_SCF_FBW7_1	0.2778
p.P154Q	DO15406	HNSC	ICGC	PTTPVAT	DEG_SCF_FBW7_1	0.2778
p.P154Q	DO37901	SKCM	ICGC	PTTPVAT	DEG_SCF_FBW7_1	0.2778
p.P165S	TCGA-FW-A3R5	SKCM	TCGA	PTTPVAT	DEG_SCF_FBW7_1	0.25
p.S171R	DO15919	HNSC	ICGC	PTTPVAT	DEG_SCF_FBW7_1	0.0833
p.P157S	DO37406	SKCM	ICGC	PTTPVAT	DEG_SCF_FBW7_1	0.6752
p.T157I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PTTPVAT	DEG_SCF_FBW7_1	0.5966
p.T157I	ACH-000981	Leukemia	CCLE	PTTPVAT	DEG_SCF_FBW7_1	0.5966
p.G153V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PTTPVAT	DEG_SCF_FBW7_1	0.25
p.G153V	ACH-000878	Lung Cancer	CCLE	PTTPVAT	DEG_SCF_FBW7_1	0.25
p.G153V	HCC-15	lung	COSMIC	PTTPVAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SCF_FBW7_1	156:162	PTTPVAT	FBXW7	0.622	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons