DegronMD

Uniprot ID: Q9H1U4

Source protein: Multiple epidermal growth factor-like domains protein 9

Source gene: MEGF9

Class: DEG_SPOP_SBC_1

Location: 111:115

E3 ligase: SPOP

DEGRON score: 0.8482

ASA_SCORE: 49.64

COIL: 0.5688

CONS_SCORE: 0.5372

DSS_SCORE: 0.68

HELIX: 0.0904

FCONS_SCORE: 1.109

RIG_SCORE: 0.6208

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E101K	TCGA-D3-A8GI	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	0.0556
p.E101K	DO50284	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	0.0556
p.L120F	TCGA-SW-A7EA	STAD	TCGA	PSSTT	DEG_SPOP_SBC_1	0.1944
p.L120F	DO51749	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1944
p.P122H	DO229028	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1389
p.A122V	DO229085	THCA	ICGC	PSSTT	DEG_SPOP_SBC_1	0.1389
p.S112A	SIDM01090	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01117	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00087	Plasma Cell Myeloma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00690	Head and Neck Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00210	Ovarian Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00311	Mesothelioma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00529	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00879	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01133	Other Solid Cancers	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00863	Burkitt's Lymphoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01681	Non-Cancerous	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00944	Colorectal Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00720	Mesothelioma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00673	Breast Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S112A	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.6477
p.S113A	SIDM00568	Gastric Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7588
p.S113A	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PSSTT	DEG_SPOP_SBC_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14776	Transcription elongation regulator 1	DEG_SPOP_SBC_1	279:283	PSSTT	SPOP	0.9606	More...
O75626	PR domain zinc finger protein 1	DEG_SPOP_SBC_1	330:334	PSSTT	SPOP	0.9804	More...
P10323	Acrosin	DEG_SPOP_SBC_1	372:376	PSSTT	SPOP	0.9214	More...
P16070	CD44 antigen	DEG_SPOP_SBC_1	389:393	PSSTT	SPOP	0.912	More...
P19801	Amiloride-sensitive amine oxidase [copper-containing]	DEG_SPOP_SBC_1	58:62	PSSTT	SPOP	0.6653	More...
P27816	Microtubule-associated protein 4	DEG_SPOP_SBC_1	913:917	PSSTT	SPOP	0.9979	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	1715:1719	PSSTT	SPOP	0.9877	More...
Q16186	Proteasomal ubiquitin receptor ADRM1	DEG_SPOP_SBC_1	218:222	PSSTT	SPOP	0.979	More...
Q6VAB6	Kinase suppressor of Ras 2	DEG_SPOP_SBC_1	521:525	PSSTT	SPOP	0.982	More...
Q8IVT5	Kinase suppressor of Ras 1	DEG_SPOP_SBC_1	448:452	PSSTT	SPOP	0.9811	More...
Q8IWE5	Pleckstrin homology domain-containing family M member 2	DEG_SPOP_SBC_1	379:383	PSSTT	SPOP	0.6967	More...
Q8IYB5	Stromal membrane-associated protein 1	DEG_SPOP_SBC_1	445:449	PSSTT	SPOP	0.9873	More...
Q8IZT6	Abnormal spindle-like microcephaly-associated protein	DEG_SPOP_SBC_1	564:568	PSSTT	SPOP	0.9996	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	2083:2087	PSSTT	SPOP	0.6521	More...
Q9BZ23	Pantothenate kinase 2, mitochondrial	DEG_SPOP_SBC_1	35:39	PSSTT	SPOP	0.9845	More...
Q9UBW5	Bridging integrator 2	DEG_SPOP_SBC_1	363:367	PSSTT	SPOP	0.9824	More...
Q6P4D5	PABIR family member 1	DEG_SPOP_SBC_1	14:18	PSSTT	SPOP	0.8064	More...
Q6UXX5	Inter-alpha-trypsin inhibitor heavy chain H6	DEG_SPOP_SBC_1	914:918	PSSTT	SPOP	0.5086	More...
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SPOP_SBC_1	111:115	PSSTT	SPOP	0.8482	More...
Q9UKJ0	Paired immunoglobulin-like type 2 receptor beta	DEG_SPOP_SBC_1	161:165	PSSTT	SPOP	0.9384	More...
Q9ULJ7	Ankyrin repeat domain-containing protein 50	DEG_SPOP_SBC_1	1235:1239	PSSTT	SPOP	0.9936	More...
Q9Y2D5	A-kinase anchor protein 2	DEG_SPOP_SBC_1	153:157	PSSTT	SPOP	0.9567	More...
Q2KHR3	Glutamine and serine-rich protein 1	DEG_SPOP_SBC_1	1195:1199	PSSTT	SPOP	0.9043	More...
Q76KD6	Speriolin	DEG_SPOP_SBC_1	351:355	PSSTT	SPOP	0.9888	More...
Q9HC44	Vasculin-like protein 1	DEG_SPOP_SBC_1	297:301	PSSTT	SPOP	0.9981	More...
Q9P2B7	Cilia- and flagella-associated protein 97	DEG_SPOP_SBC_1	234:238	PSSTT	SPOP	0.9913	More...
A6NM66	Uncharacterized protein encoded by LINC01548	DEG_SPOP_SBC_1	82:86	PSSTT	SPOP	0.6139	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTT

Degron related mutations and impact score

Drug responses associated with MEGF9 mutations

All proteins holding degron of PSSTT