DegronMD - P19801(AOC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L36I	TCGA-05-4250	LUAD	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.3056
p.L36I	DO24457	LUAD	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.3056
p.T68S	TCGA-05-4390	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation blocking phosphorylation signal	0.6111
p.T68S	DO23562	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation blocking phosphorylation signal	0.6111
p.T63I	TCGA-24-1428	OV	TCGA	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation blocking phosphorylation signal	0.75
p.T63I	DO29298	OV	ICGC	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation blocking phosphorylation signal	0.75
p.P23L	TCGA-32-2616	GBM	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1667
p.P23L	DO13462	GBM	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1667
p.P58T	TCGA-49-AARE	LUAD	TCGA	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7031
p.P58T	DO218922	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation altering degron motif	0.7031
p.L36P	TCGA-A8-A09Z	BRCA	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.3056
p.L36P	DO5521	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.3056
p.V32M	DO225186	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.6097
p.V32M	DO227932	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation altering degron motif	0.6097
p.L71I	DO232030	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.0833
p.A65S	DO229041	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	58:62	Mutation rewiring degron network	0.25
p.G24E	DO219873	SKCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1944
p.E20K	SIDM00953	Small Cell Lung Carcinoma	GDSC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.0833
p.E20K	CPC-N	lung	COSMIC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.0833
p.P21H	ACH-000860	Lung Cancer	CCLE	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1111
p.P21H	NCI-H358	lung	COSMIC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	29:35	Mutation rewiring degron network	0.1111

Kaplan plot for AOC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AOC1

UniProt ID: P19801

Entrez ID: 26

Protein name: Amiloride-sensitive amine oxidase [copper-containing] (DAO) (Diamine oxidase) (EC 1.4.3.22) (Amiloride-binding protein 1) (Amine oxidase copper domain-containing protein 1) (Histaminase) (Kidney amine oxidase) (KAO)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AOC1 in