DegronMD

Uniprot ID: P19801

Source protein: Amiloride-sensitive amine oxidase [copper-containing]

Source gene: AOC1

Class: LIG_APCC_ABBAyCdc20_2

Location: 29:35

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5711

ASA_SCORE: 55.4714

COIL: 0.8416

CONS_SCORE: 0.3692

DSS_SCORE: 0.3847

HELIX: 0.117

FCONS_SCORE: 0.9459

RIG_SCORE: 0.7466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L36I	TCGA-05-4250	LUAD	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L36I	DO24457	LUAD	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P23L	TCGA-32-2616	GBM	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P23L	DO13462	GBM	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L36P	TCGA-A8-A09Z	BRCA	TCGA	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L36P	DO5521	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.3056
p.V32M	DO225186	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V32M	DO227932	BRCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.6097
p.G24E	DO219873	SKCA	ICGC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E20K	SIDM00953	Small Cell Lung Carcinoma	GDSC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E20K	CPC-N	lung	COSMIC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P21H	ACH-000860	Lung Cancer	CCLE	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P21H	NCI-H358	lung	COSMIC	KAGVFSD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P19801	Amiloride-sensitive amine oxidase [copper-containing]	LIG_APCC_ABBAyCdc20_2	29:35	KAGVFSD	APC,CDC20,FZR1	0.5711	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons