DegronMD - Q9Y2D5(AKAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G166R	DO225328	BRCA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0833
p.T161M	DO1129	BRCA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2222
p.S155T	DO3146	BRCA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.7116
p.P421L	DO3110	BRCA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.2778
p.A650V	DO222967	BTCA	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1667
p.R416C	DO51615	CESC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1389
p.C148Y	DO10068	COAD	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.E653G	DO10341	COAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.0833
p.S162N	DO227549	COCA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.E150D	DO233871	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.25
p.A164V	DO233888	GACA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1389
p.A164V	DO41752	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1389
p.F633I	DO13378	GBM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.25
p.G637D	DO11854	GBM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation altering degron motif	0.7198
p.V629I	DO14246	HNSC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.V629I	DO42608	UCEC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.V629I	HGC-27	stomach	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.V629I	HSC-3	upper aerodigestive tract	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.V629I	OVMIU	ovary	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.V629I	SAT	upper aerodigestive tract	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1389
p.R164Q	DO14188	HNSC	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1389
p.G432S	DO21833	LAML	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.3056
p.I441M	DO228239	LICA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.0556
p.C148F	DO229029	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.R150L	DO229029	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.25
p.R150L	DO229035	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.25
p.V167F	DO229037	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0556
p.C154F	DO229006	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.7108
p.A415S	DO229006	LICA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.1111
p.G626V	DO218944	LUAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.0556
p.Y162F	DO25471	LUAD	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1944
p.G646W	DO26540	LUSC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.2778
p.T151R	DO219177	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2778
p.R150Q	DO51717	PAAD	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.25
p.R150Q	DO47646	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.25
p.L147F	DO223908	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.1667
p.R652M	DO38177	SKCM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.1111
p.C161W	DO38883	STAD	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2222
p.K645E	DO222342	STAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation rewiring degron network	0.3056
p.S413F	DO43642	UCEC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.0556
p.P154S	DO42280	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation altering degron motif	0.6752
p.A151T	DO41584	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.2778
p.S413P	DO43971	UCEC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.0556
p.G413E	WM793B	skin	COSMIC	KRGPLSKLW	DEG_APCC_DBOX_1	423:431	Mutation rewiring degron network	0.0556
p.R143G	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	153:157	Mutation rewiring degron network	0.0556
p.G637S	NCI-SNU-1	stomach	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	636:644	Mutation altering degron motif	0.6993

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AKAP2

UniProt ID: Q9Y2D5

Entrez ID: 445815

Protein name: A-kinase anchor protein 2 (AKAP-2) (AKAP-KL) (Protein kinase A-anchoring protein 2) (PRKA2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AKAP2 in