DegronMD

Uniprot ID: Q9Y2D5

Source protein: A-kinase anchor protein 2

Source gene: AKAP2

Class: DEG_APCC_DBOX_1

Location: 423:431

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8543

ASA_SCORE: 93.5556

COIL: 0.702

CONS_SCORE: 0.3796

DSS_SCORE: 0.5439

HELIX: 0.1574

FCONS_SCORE: 0.5569

RIG_SCORE: 0.685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P421L	DO3110	BRCA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.2778
p.R416C	DO51615	CESC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.1389
p.G432S	DO21833	LAML	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.3056
p.I441M	DO228239	LICA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.0556
p.A415S	DO229006	LICA	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.1111
p.S413F	DO43642	UCEC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.0556
p.S413P	DO43971	UCEC	ICGC	KRGPLSKLW	DEG_APCC_DBOX_1	0.0556
p.G413E	WM793B	skin	COSMIC	KRGPLSKLW	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2D5	A-kinase anchor protein 2	DEG_APCC_DBOX_1	423:431	KRGPLSKLW	APC,CDC20,FZR1	0.8543	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons