DegronMD

Uniprot ID: Q9Y2D5

Source protein: A-kinase anchor protein 2

Source gene: AKAP2

Class: DEG_APCC_DBOX_1

Location: 636:644

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9824

ASA_SCORE: 98.4

COIL: 0.8542

CONS_SCORE: 0.6201

DSS_SCORE: 0.6166

HELIX: 0.0958

FCONS_SCORE: 0.9974

RIG_SCORE: 0.7326

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A650V	DO222967	BTCA	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1667
p.E653G	DO10341	COAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.0833
p.F633I	DO13378	GBM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.25
p.G637D	DO11854	GBM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.7198
p.V629I	DO14246	HNSC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.V629I	DO42608	UCEC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.V629I	HGC-27	stomach	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.V629I	HSC-3	upper_aerodigestive_tract	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.V629I	OVMIU	ovary	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.V629I	SAT	upper_aerodigestive_tract	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1389
p.G626V	DO218944	LUAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.0556
p.G646W	DO26540	LUSC	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.2778
p.R652M	DO38177	SKCM	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.1111
p.K645E	DO222342	STAD	ICGC	KRDVLPKIL	DEG_APCC_DBOX_1	0.3056
p.G637S	NCI-SNU-1	stomach	COSMIC	KRDVLPKIL	DEG_APCC_DBOX_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2D5	A-kinase anchor protein 2	DEG_APCC_DBOX_1	636:644	KRDVLPKIL	APC,CDC20,FZR1	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons