DegronMD - Q9UBW5(BIN2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E353K	TCGA-56-8307	LUSC	TCGA	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0556
p.E353K	DO219139	LUSC	ICGC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.0556
p.E485A	TCGA-A5-A2K5	UCEC	TCGA	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation altering degron motif	0.659
p.L374M	TCGA-BF-A1PU	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.L374M	DO50278	SKCM	ICGC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.E483K	TCGA-DA-A95Z	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation altering degron motif	0.7022
p.P363S	TCGA-EE-A29E	SKCM	TCGA	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.6752
p.E485K	TCGA-EE-A29M	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation altering degron motif	0.591
p.E485K	TCGA-FS-A1ZZ	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation altering degron motif	0.591
p.E494K	TCGA-FR-A8YC	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.0833
p.E494K	DO50301	SKCM	ICGC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.0833
p.S371T	DO231974	LICA	ICGC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2222
p.P475T	DO228974	LICA	ICGC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.1667
p.L362I	DO42793	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.R365H	DO42753	UCEC	ICGC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.8244
p.P480H	SIDM01608	Endometrial Carcinoma	GDSC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.3056
p.G474W	SIDM01608	Endometrial Carcinoma	GDSC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation substituting flanking lysine	0.25
p.S369T	ACH-000220	Lymphoma	CCLE	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.N489H	ACH-000734	Liver Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.2222
p.S357Y	ACH-000945	Lung Cancer	CCLE	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.6111
p.P492A	ACH-001098	Pancreatic Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.1389
p.R477K	ACH-002166	Skin Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.2222
p.D492N	MZ7-mel	skin	COSMIC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.1389
p.D492N	JSC-1	haematopoietic and lymphoid tissue	COSMIC	AKENE	DEG_APCC_KENBOX_2	481:485	Mutation rewiring degron network	0.1389
p.R366C	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.8301
p.R366C	KY821	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.8301
p.R366C	NY	bone	COSMIC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.8301
p.R366H	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSSTT	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.8244

Kaplan plot for BIN2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BIN2

UniProt ID: Q9UBW5

Entrez ID: 51411

Protein name: Bridging integrator 2 (Breast cancer-associated protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for BIN2 in