DegronMD

Uniprot ID: Q9UBW5

Source protein: Bridging integrator 2

Source gene: BIN2

Class: DEG_APCC_KENBOX_2

Location: 481:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8948

ASA_SCORE: 101.18

COIL: 0.6132

CONS_SCORE: 0.4148

DSS_SCORE: 0.7794

HELIX: 0.3862

FCONS_SCORE: 1.0082

RIG_SCORE: 0.6127

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E485A	TCGA-A5-A2K5	UCEC	TCGA	AKENE	DEG_APCC_KENBOX_2	0.659
p.E483K	TCGA-DA-A95Z	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	0.7022
p.E485K	TCGA-EE-A29M	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	0.591
p.E485K	TCGA-FS-A1ZZ	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	0.591
p.E494K	TCGA-FR-A8YC	SKCM	TCGA	AKENE	DEG_APCC_KENBOX_2	0.0833
p.E494K	DO50301	SKCM	ICGC	AKENE	DEG_APCC_KENBOX_2	0.0833
p.P475T	DO228974	LICA	ICGC	AKENE	DEG_APCC_KENBOX_2	0.1667
p.P480H	SIDM01608	Endometrial Carcinoma	GDSC	AKENE	DEG_APCC_KENBOX_2	0.3056
p.G474W	SIDM01608	Endometrial Carcinoma	GDSC	AKENE	DEG_APCC_KENBOX_2	0.25
p.N489H	ACH-000734	Liver Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	0.2222
p.P492A	ACH-001098	Pancreatic Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	0.1389
p.R477K	ACH-002166	Skin Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	0.2222
p.D492N	MZ7-mel	skin	COSMIC	AKENE	DEG_APCC_KENBOX_2	0.1389
p.D492N	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	AKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	303:307	AKENE	APC,CDC20,FZR1	0.9884	More...
Q9UBW5	Bridging integrator 2	DEG_APCC_KENBOX_2	481:485	AKENE	APC,CDC20,FZR1	0.8948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons