DegronMD

Uniprot ID: O60566

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Source gene: BUB1B

Class: DEG_APCC_KENBOX_2

Location: 303:307

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9884

ASA_SCORE: 93.96

COIL: 0.7096

CONS_SCORE: 0.375

DSS_SCORE: 0.6172

HELIX: 0.2378

FCONS_SCORE: 1.1099

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L308P	TCGA-AA-3949	COAD	TCGA	AKENE	DEG_APCC_KENBOX_2	0.3056
p.L308P	DO7798	COAD	ICGC	AKENE	DEG_APCC_KENBOX_2	0.3056
p.R302G	TCGA-FI-A2D5	UCEC	TCGA	AKENE	DEG_APCC_KENBOX_2	0.3056
p.R302G	DO41331	UCEC	ICGC	AKENE	DEG_APCC_KENBOX_2	0.3056
p.G316C	DO229028	LICA	ICGC	AKENE	DEG_APCC_KENBOX_2	0.0833
p.P294Q	ACH-001061	Colon/Colorectal Cancer	CCLE	AKENE	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	DEG_APCC_KENBOX_2	303:307	AKENE	APC,CDC20,FZR1	0.9884	More...
Q9UBW5	Bridging integrator 2	DEG_APCC_KENBOX_2	481:485	AKENE	APC,CDC20,FZR1	0.8948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons