DegronMD

Uniprot ID: Q9H1U4

Source protein: Multiple epidermal growth factor-like domains protein 9

Source gene: MEGF9

Class: DEG_SCF_FBW7_1

Location: 185:192

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 54.825

COIL: 0.7676

CONS_SCORE: 0.6325

DSS_SCORE: 0.6723

HELIX: 0.0653

FCONS_SCORE: 1.3051

RIG_SCORE: 0.5833

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S188C	DO481	BLCA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.7541
p.S184N	SIDM01591	Breast Carcinoma	GDSC	VLPTPPAT	DEG_SCF_FBW7_1	0.3056
p.S184N	ACH-000540	Non-Cancerous	CCLE	VLPTPPAT	DEG_SCF_FBW7_1	0.3056
p.P195T	DO227996	COCA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.25
p.Q195P	DO23108	LINC	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.25
p.Q195P	DO45041	LINC	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.25
p.S196C	TCGA-DK-A3WW	BLCA	TCGA	VLPTPPAT	DEG_SCF_FBW7_1	0.2222
p.S180R	DO229015	LICA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.1944
p.S179R	TCGA-CV-6941	HNSC	TCGA	VLPTPPAT	DEG_SCF_FBW7_1	0.1667
p.P202L	DO229036	LICA	ICGC	VLPTPPAT	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H1U4	Multiple epidermal growth factor-like domains protein 9	DEG_SCF_FBW7_1	185:192	VLPTPPAT	FBXW7	0.995	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons