DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PQPTPKME
Uniprot ID:
O75179
Source protein:
Ankyrin repeat domain-containing protein 17
Source gene:
ANKRD17
Class:
DEG_SCF_FBW7_2
Location:
2167:2174
E3 ligase:
FBXW7
DEGRON score:
0.8913
ASA_SCORE:
100.6375
COIL:
0.939
CONS_SCORE:
0.3541
DSS_SCORE:
0.6907
HELIX:
0.0281
FCONS_SCORE:
0.9435
RIG_SCORE:
0.6192
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S2172L
DO24692
LUAD
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.7667
p.P2167T
DO34905
PACA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.7031
p.S2172P
DO2937
BRCA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.6752
p.K2172N
ACH-002061
Leukemia
CCLE
PQPTPKME
DEG_SCF_FBW7_2
0.5806
p.C2166Y
TCGA-HU-A4H8
STAD
TCGA
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.T2175S
SIDM00261
Ewing's Sarcoma
GDSC
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.T2175S
ACH-002109
Bone Cancer
CCLE
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.T2175S
ES8
bone
COSMIC
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.T2175A
SIDM01608
Endometrial Carcinoma
GDSC
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.T2175A
ACH-000990
Endometrial/Uterine Cancer
CCLE
PQPTPKME
DEG_SCF_FBW7_2
0.3056
p.S2165P
SNU-1040
large_intestine
COSMIC
PQPTPKME
DEG_SCF_FBW7_2
0.2778
p.A2177P
TCGA-CN-6994
HNSC
TCGA
PQPTPKME
DEG_SCF_FBW7_2
0.25
p.P2179T
DO228976
LICA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.1944
p.P2179L
DO25603
LUAD
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.1944
p.Q2161L
TCGA-CV-6933
HNSC
TCGA
PQPTPKME
DEG_SCF_FBW7_2
0.1667
p.P2180A
TCGA-D8-A1JA
BRCA
TCGA
PQPTPKME
DEG_SCF_FBW7_2
0.1667
p.S2181L
DO225329
BRCA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.1389
p.S2159P
OCI-AML5
haematopoietic_and_lymphoid_tissue
COSMIC
PQPTPKME
DEG_SCF_FBW7_2
0.1111
p.S2159P
Daudi
haematopoietic_and_lymphoid_tissue
COSMIC
PQPTPKME
DEG_SCF_FBW7_2
0.1111
p.S2159P
DND-41
haematopoietic_and_lymphoid_tissue
COSMIC
PQPTPKME
DEG_SCF_FBW7_2
0.1111
p.H2183D
TCGA-D8-A1JA
BRCA
TCGA
PQPTPKME
DEG_SCF_FBW7_2
0.0833
p.P2183S
DO225329
BRCA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.0833
p.G2158A
DO228377
LICA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.0833
p.P2183H
DO232761
PBCA
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.0833
p.P2183H
DO41020
UCEC
ICGC
PQPTPKME
DEG_SCF_FBW7_2
0.0833
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Drug responses associated with ANKRD17 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PQPTPKME
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75179
Ankyrin repeat domain-containing protein 17
DEG_SCF_FBW7_2
2167:2174
PQPTPKME
FBXW7
0.8913
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