DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SCF_FBW7_2

Location: 2167:2174

E3 ligase: FBXW7

DEGRON score: 0.8913

ASA_SCORE: 100.6375

COIL: 0.939

CONS_SCORE: 0.3541

DSS_SCORE: 0.6907

HELIX: 0.0281

FCONS_SCORE: 0.9435

RIG_SCORE: 0.6192

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2177P	TCGA-CN-6994	HNSC	TCGA	PQPTPKME	DEG_SCF_FBW7_2	0.25
p.Q2161L	TCGA-CV-6933	HNSC	TCGA	PQPTPKME	DEG_SCF_FBW7_2	0.1667
p.H2183D	TCGA-D8-A1JA	BRCA	TCGA	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.P2180A	TCGA-D8-A1JA	BRCA	TCGA	PQPTPKME	DEG_SCF_FBW7_2	0.1667
p.C2166Y	TCGA-HU-A4H8	STAD	TCGA	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.P2183S	DO225329	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.S2181L	DO225329	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.1389
p.S2172P	DO2937	BRCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.6752
p.G2158A	DO228377	LICA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.P2179T	DO228976	LICA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.1944
p.P2179L	DO25603	LUAD	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.1944
p.S2172L	DO24692	LUAD	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.7667
p.P2167T	DO34905	PACA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.7031
p.P2183H	DO232761	PBCA	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.P2183H	DO41020	UCEC	ICGC	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.T2175S	SIDM00261	Ewing's Sarcoma	GDSC	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.T2175S	ACH-002109	Bone Cancer	CCLE	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.T2175S	ES8	bone	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.T2175A	SIDM01608	Endometrial Carcinoma	GDSC	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.T2175A	ACH-000990	Endometrial/Uterine Cancer	CCLE	PQPTPKME	DEG_SCF_FBW7_2	0.3056
p.K2172N	ACH-002061	Leukemia	CCLE	PQPTPKME	DEG_SCF_FBW7_2	0.5806
p.S2159P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.1111
p.S2159P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.1111
p.S2159P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.1111
p.R2183C	SNU-1040	large_intestine	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.0833
p.S2165P	SNU-1040	large_intestine	COSMIC	PQPTPKME	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_2	2167:2174	PQPTPKME	FBXW7	0.8913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQPTPKME

Degron related mutations and impact score

Drug responses associated with ANKRD17 mutations

All proteins holding degron of PQPTPKME