DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SCF_FBW7_1

Location: 2507:2513

E3 ligase: FBXW7

DEGRON score: 0.9123

ASA_SCORE: 56.3571

COIL: 0.765

CONS_SCORE: 0.406

DSS_SCORE: 0.5334

HELIX: 0.064

FCONS_SCORE: 0.9938

RIG_SCORE: 0.6637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2498E	TCGA-22-5474	LUSC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	0.0833
p.Q2516R	TCGA-BS-A0UF	UCEC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	0.25
p.E2501A	TCGA-DD-AADR	LIHC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	0.1667
p.R2502Q	TCGA-EY-A1G8	UCEC	TCGA	IVTPSGT	DEG_SCF_FBW7_1	0.1944
p.M2500T	SIDM01307	Colorectal Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	0.1389
p.G2512A	SIDM00928	Breast Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	0.6429
p.G2512A	CAL-85-1	breast	COSMIC	IVTPSGT	DEG_SCF_FBW7_1	0.6429
p.G2506A	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	IVTPSGT	DEG_SCF_FBW7_1	0.3056
p.G2506A	ACH-000638	Lung Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	0.3056
p.G2506A	NCI-H441	lung	COSMIC	IVTPSGT	DEG_SCF_FBW7_1	0.3056
p.R2502P	ACH-001172	Brain Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	0.1944
p.V2518I	ACH-002680	Brain Cancer	CCLE	IVTPSGT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	2507:2513	IVTPSGT	FBXW7	0.9123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons