DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SCF_FBW7_1

Location: 2377:2383

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 77

COIL: 0.8986

CONS_SCORE: 0.3718

DSS_SCORE: 0.47

HELIX: 0.073

FCONS_SCORE: 0.992

RIG_SCORE: 0.6934

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q2391K	TCGA-69-7974	LUAD	TCGA	LLTPCSS	DEG_SCF_FBW7_1	0.1111
p.S2373P	TCGA-BG-A0MQ	UCEC	TCGA	LLTPCSS	DEG_SCF_FBW7_1	0.6667
p.A2384T	TCGA-BR-4361	STAD	TCGA	LLTPCSS	DEG_SCF_FBW7_1	0.3056
p.S2388Y	TCGA-F5-6814	READ	TCGA	LLTPCSS	DEG_SCF_FBW7_1	0.1944
p.P2369L	DO10871	GBM	ICGC	LLTPCSS	DEG_SCF_FBW7_1	0.1111
p.E2388A	DO52245	LIHC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	0.1944
p.Q2385E	DO26578	LUSC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	0.2778
p.E2388D	DO229257	THCA	ICGC	LLTPCSS	DEG_SCF_FBW7_1	0.1944
p.R2389Q	DO43578	UCEC	ICGC	LLTPCSS	DEG_SCF_FBW7_1	0.1667
p.N2386D	SIDM01611	Endometrial Carcinoma	GDSC	LLTPCSS	DEG_SCF_FBW7_1	0.25
p.N2386D	ACH-000996	Endometrial/Uterine Cancer	CCLE	LLTPCSS	DEG_SCF_FBW7_1	0.25
p.S2373Y	ACH-001864	Bile Duct Cancer	CCLE	LLTPCSS	DEG_SCF_FBW7_1	0.6667
p.G2393A	NCI-H441	lung	COSMIC	LLTPCSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SCF_FBW7_1	2377:2383	LLTPCSS	FBXW7	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons