DegronMD

Uniprot ID: O75179

Source protein: Ankyrin repeat domain-containing protein 17

Source gene: ANKRD17

Class: DEG_SPOP_SBC_1

Location: 2093:2097

E3 ligase: SPOP

DEGRON score: 0.9431

ASA_SCORE: 96.92

COIL: 0.9596

CONS_SCORE: 0.3722

DSS_SCORE: 0.8028

HELIX: 0.021

FCONS_SCORE: 0.9262

RIG_SCORE: 0.457

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2105D	TCGA-CV-7415	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1111
p.R2091S	TCGA-EO-A22X	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.2778
p.S2100R	DO228627	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.25
p.A2088E	DO229022	LICA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.S2104F	DO25426	LUAD	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1389
p.Q2083L	DO223720	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.S2100G	DO219136	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.25
p.V2092F	DO229494	SKCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.R2097K	DO48626	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.7237
p.S2097I	SIDM00094	Kidney Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.7341
p.S2097I	ACH-002199	Kidney Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.7341
p.S2097I	SN12C	kidney	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.7341
p.S2106C	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S2106C	ACH-000662	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S2106C	COR-L23	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.0833
p.S2091N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2778
p.N2093H	NCI-H1299	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.7423
p.H2087Q	NCI-H1876	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.A2105S	MC116	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.1111
p.P2106S	CS1	bone	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with ANKRD17 mutations

All proteins holding degron of PNSSS