DegronMD - Q9NQ87(HEYL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S39L	TCGA-A5-A0G2	UCEC	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation altering degron motif	0.7667
p.A30T	TCGA-AD-5900	COAD	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.A30V	TCGA-AG-A002	READ	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.H47Y	TCGA-BR-6566	STAD	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.1111
p.K45N	TCGA-E7-A7DV	BLCA	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation substituting flanking lysine	0.2778
p.S27T	TCGA-G2-A2ES	BLCA	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.1944
p.S27T	DO785	BLCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.1944
p.R27H	DO44153	BRCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.1944
p.L38V	DO6308	CESC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation altering degron motif	0.6765
p.R40C	DO8192	COAD	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.3056
p.R30C	DO52450	COCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.R30C	DO30990	OV	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.R30H	DO10880	GBM	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.R30H	DO41572	UCEC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.2778
p.L38M	DO42472	UCEC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation altering degron motif	0.711
p.P296L	SIDM00057	Neuroblastoma	GDSC	VPTPNSS	DEG_SCF_FBW7_1	295:301	Mutation altering degron motif	0.6471
p.P296L	ACH-000676	Brain Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	295:301	Mutation altering degron motif	0.6471
p.A310E	ACH-000830	Lung Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	295:301	Mutation rewiring degron network	0.0833
p.A310E	ACH-000830	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111
p.G49R	ACH-001645	Skin Cancer	CCLE	PLSTPSSS	DEG_SCF_FBW7_1	32:39	Mutation rewiring degron network	0.0556
p.A310V	ACH-001664	Gastric Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	295:301	Mutation rewiring degron network	0.0833
p.A310V	ACH-001664	Gastric Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	298:302	Mutation rewiring degron network	0.1111

Kaplan plot for HEYL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEYL

UniProt ID: Q9NQ87

Entrez ID: 26508

Protein name: Hairy/enhancer-of-split related with YRPW motif-like protein (hHeyL) (Class B basic helix-loop-helix protein 33) (bHLHb33) (Hairy-related transcription factor 3) (HRT-3) (hHRT3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEYL in