DegronMD

Uniprot ID: Q9NQ87

Source protein: Hairy/enhancer-of-split related with YRPW motif-like protein

Source gene: HEYL

Class: DEG_SCF_FBW7_1

Location: 32:39

E3 ligase: FBXW7

DEGRON score: 0.7395

ASA_SCORE: 95.45

COIL: 0.926

CONS_SCORE: 0.5156

DSS_SCORE: 0.8141

HELIX: 0.0654

FCONS_SCORE: 0.9751

RIG_SCORE: 0.6034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S39L	TCGA-A5-A0G2	UCEC	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.7667
p.A30T	TCGA-AD-5900	COAD	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.A30V	TCGA-AG-A002	READ	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.H47Y	TCGA-BR-6566	STAD	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.1111
p.K45N	TCGA-E7-A7DV	BLCA	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.S27T	TCGA-G2-A2ES	BLCA	TCGA	PLSTPSSS	DEG_SCF_FBW7_1	0.1944
p.S27T	DO785	BLCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.1944
p.R27H	DO44153	BRCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.1944
p.L38V	DO6308	CESC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.6765
p.R40C	DO8192	COAD	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.3056
p.R30C	DO52450	COCA	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.R30C	DO30990	OV	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.R30H	DO10880	GBM	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.R30H	DO41572	UCEC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.2778
p.L38M	DO42472	UCEC	ICGC	PLSTPSSS	DEG_SCF_FBW7_1	0.711
p.G49R	ACH-001645	Skin Cancer	CCLE	PLSTPSSS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SCF_FBW7_1	32:39	PLSTPSSS	FBXW7	0.7395	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons