DegronMD

Uniprot ID: Q9NQ87

Source protein: Hairy/enhancer-of-split related with YRPW motif-like protein

Source gene: HEYL

Class: DEG_SCF_FBW7_1

Location: 295:301

E3 ligase: FBXW7

DEGRON score: 0.9311

ASA_SCORE: 93.9857

COIL: 0.9773

CONS_SCORE: 0.3975

DSS_SCORE: 0.5281

HELIX: 0.009

FCONS_SCORE: 0.9328

RIG_SCORE: 0.6102

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P296L	SIDM00057	Neuroblastoma	GDSC	VPTPNSS	DEG_SCF_FBW7_1	0.6471
p.P296L	ACH-000676	Brain Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	0.6471
p.A310E	ACH-000830	Lung Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	0.0833
p.A310V	ACH-001664	Gastric Cancer	CCLE	VPTPNSS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SCF_FBW7_1	295:301	VPTPNSS	FBXW7	0.9311	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons