DegronMD

Uniprot ID: P56177

Source protein: Homeobox protein DLX-1

Source gene: DLX1

Class: DEG_SPOP_SBC_1

Location: 218:222

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 58.64

COIL: 0.9212

CONS_SCORE: 0.4593

DSS_SCORE: 0.6525

HELIX: 0.0388

FCONS_SCORE: 1.0585

RIG_SCORE: 0.5672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G223V	TCGA-85-6561	LUSC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.3056
p.G223V	DO26518	LUSC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.G228E	TCGA-EE-A2GI	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1667
p.G228E	DO37410	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1667
p.N219T	TCGA-EO-A3B0	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	0.5944
p.N219T	DO219773	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	0.5944
p.G223E	TCGA-FD-A5BT	BLCA	TCGA	PNSSS	DEG_SPOP_SBC_1	0.3056
p.G223E	DO44032	BLCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.3056
p.P210S	TCGA-RP-A695	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	0.1111
p.P210S	DO51270	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	0.1111
p.S232F	DO229453	SKCA	ICGC	PNSSS	DEG_SPOP_SBC_1	0.0556
p.P213L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.P213L	ACH-002256	Leukemia	CCLE	PNSSS	DEG_SPOP_SBC_1	0.1944
p.P213L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.1944
p.P214T	SIDM00333	Endometrial Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	0.2222
p.P214T	ACH-000988	Endometrial/Uterine Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	0.2222
p.P214T	MFE-319	endometrium	COSMIC	PNSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15117	FYN-binding protein 1	DEG_SPOP_SBC_1	26:30	PNSSS	SPOP	0.994	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	7:11	PNSSS	SPOP	0.7976	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	2093:2097	PNSSS	SPOP	0.9431	More...
O94812	BAI1-associated protein 3	DEG_SPOP_SBC_1	423:427	PNSSS	SPOP	0.6757	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1389:1393	PNSSS	SPOP	0.9056	More...
P56177	Homeobox protein DLX-1	DEG_SPOP_SBC_1	218:222	PNSSS	SPOP	0.9889	More...
Q16666	Gamma-interferon-inducible protein 16	DEG_SPOP_SBC_1	177:181	PNSSS	SPOP	0.9508	More...
Q16832	Discoidin domain-containing receptor 2	DEG_SPOP_SBC_1	672:676	PNSSS	SPOP	0.678	More...
Q659A1	Little elongation complex subunit 2	DEG_SPOP_SBC_1	606:610	PNSSS	SPOP	0.9659	More...
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SPOP_SBC_1	9:13	PNSSS	SPOP	0.6156	More...
Q86V97	Kelch repeat and BTB domain-containing protein 6	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.8742	More...
Q8IZQ8	Myocardin	DEG_SPOP_SBC_1	334:338	PNSSS	SPOP	0.9909	More...
Q8N9N5	Protein BANP	DEG_SPOP_SBC_1	338:342	PNSSS	SPOP	0.9929	More...
Q8NHG8	E3 ubiquitin-protein ligase ZNRF2	DEG_SPOP_SBC_1	104:108	PNSSS	SPOP	0.9921	More...
Q8WVZ9	Kelch repeat and BTB domain-containing protein 7	DEG_SPOP_SBC_1	315:319	PNSSS	SPOP	0.9389	More...
Q8WXX7	Autism susceptibility gene 2 protein	DEG_SPOP_SBC_1	1008:1012	PNSSS	SPOP	0.7835	More...
Q96N67	Dedicator of cytokinesis protein 7	DEG_SPOP_SBC_1	860:864	PNSSS	SPOP	0.9622	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	216:220	PNSSS	SPOP	0.9952	More...
Q9NQ87	Hairy/enhancer-of-split related with YRPW motif-like protein	DEG_SPOP_SBC_1	298:302	PNSSS	SPOP	0.9384	More...
Q9ULH7	Myocardin-related transcription factor B	DEG_SPOP_SBC_1	1056:1060	PNSSS	SPOP	0.9777	More...
Q15434	RNA-binding motif, single-stranded-interacting protein 2	DEG_SPOP_SBC_1	41:45	PNSSS	SPOP	0.6568	More...
Q9BXY5	Calcyphosin-2	DEG_SPOP_SBC_1	92:96	PNSSS	SPOP	0.9192	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNSSS

Degron related mutations and impact score

Drug responses associated with DLX1 mutations

All proteins holding degron of PNSSS