DegronMD - Q7L7V1(DHX32)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C402Y	TCGA-A5-A1OF	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.1111
p.E3K	TCGA-CV-A45Q	HNSC	TCGA	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.E3K	DO49060	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.S13F	TCGA-D3-A51G	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.7982
p.S13F	DO47700	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.7982
p.A409V	TCGA-DF-A2KN	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.3056
p.P19S	TCGA-EE-A2MR	SKCM	TCGA	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.P19S	DO37819	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1667
p.F400C	TCGA-EO-A3AY	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.0556
p.F400C	DO43202	UCEC	ICGC	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.0556
p.N10K	TCGA-FI-A2D5	UCEC	TCGA	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.5806
p.N10K	DO41331	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.5806
p.S18L	DO51650	CESC	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.1944
p.R16C	DO233137	GACA	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.25
p.R16C	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.25
p.R12C	DO49067	HNSC	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.8301
p.R12C	DO41871	UCEC	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation altering degron motif	0.8301
p.Q422R	DO222363	MELA	ICGC	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	410:417	Mutation rewiring degron network	0.1944
p.L16F	DO47559	SKCM	ICGC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.25
p.E7K	SIDM00924	Other Solid Cancers	GDSC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2778
p.E7K	ACH-000867	Lung Cancer	CCLE	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2778
p.E7K	ChaGo-K-1	lung	COSMIC	PNSSS	DEG_SPOP_SBC_1	9:13	Mutation rewiring degron network	0.2778

Kaplan plot for DHX32 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DHX32

UniProt ID: Q7L7V1

Entrez ID: 55760

Protein name: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC 3.6.4.13) (DEAD/H box 32) (DEAD/H helicase-like protein 1) (DHLP1) (DEAH box protein 32) (HuDDX32)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DHX32 in