DegronMD

Uniprot ID: Q7L7V1

Source protein: Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

Source gene: DHX32

Class: DEG_SCF_SKP2-CKS1_1

Location: 410:417

E3 ligase: SKP2,CSK1

DEGRON score: 0.8225

ASA_SCORE: 83.1125

COIL: 0.7189

CONS_SCORE: 0.4444

DSS_SCORE: 0.3314

HELIX: 0.2605

FCONS_SCORE: 0.6658

RIG_SCORE: 0.7832

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C402Y	TCGA-A5-A1OF	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	0.1111
p.A409V	TCGA-DF-A2KN	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	0.3056
p.F400C	TCGA-EO-A3AY	UCEC	TCGA	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.F400C	DO43202	UCEC	ICGC	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q422R	DO222363	MELA	ICGC	SKDMTPLK	DEG_SCF_SKP2-CKS1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L7V1	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32	DEG_SCF_SKP2-CKS1_1	410:417	SKDMTPLK	SKP2,CSK1	0.8225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons